CATH Classification

Domain Context

CATH Clusters

Superfamily 2-enoyl-CoA Hydratase; Chain A, domain 1
Functional Family 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial

Enzyme Information

3.1.2.4
3-hydroxyisobutyryl-CoA hydrolase.
based on mapping to UniProt Q6NVY1
3-hydroxy-2-methylpropanoyl-CoA + H(2)O = CoA + 3-hydroxy-2- methylpropanoate.
-!- Also hydrolyzes 3-hydroxypropanoyl-CoA.

UniProtKB Entries (1)

Q6NVY1
HIBCH_HUMAN
Homo sapiens
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial

PDB Structure

PDB 3BPT
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of human beta-hydroxyisobutyryl-CoA hydrolase in complex with quercetin.
Pilka, E.S., Phillips, C., King, O.N.F., Guo, K., von Delft, F., Pike, A.C.W., Arrowsmith, C.H., Weigelt, J., Edwards, A.M., Oppermann, U.
To be Published