CATH Classification

Domain Context

CATH Clusters

Superfamily Isopropylmalate Dehydrogenase
Functional Family Isocitrate dehydrogenase [NAD] subunit, mitochondrial

Enzyme Information

1.1.1.41
Isocitrate dehydrogenase (NAD(+)).
based on mapping to UniProt P28834
Isocitrate + NAD(+) = 2-oxoglutarate + CO(2) + NADH.
-!- Unlike EC 1.1.1.42, oxalosuccinate cannot be used as a substrate. -!- In eukaryotes, isocitrate dehydrogenase exists in two forms: an NAD(+)-linked enzyme found only in mitochondria and displaying allosteric properties, and a non-allosteric, NADP(+)-linked enzyme that is found in both mitochondria and cytoplasm. -!- The enzyme from some species can also use NADP(+) but much more slowly.

UniProtKB Entries (1)

P28241
IDH2_YEAST
Saccharomyces cerevisiae S288C
Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial

PDB Structure

PDB 3BLX
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Allosteric Motions in Structures of Yeast NAD+-specific Isocitrate Dehydrogenase.
Taylor, A.B., Hu, G., Hart, P.J., McAlister-Henn, L.
J.Biol.Chem.