CATH Classification

Domain Context

CATH Clusters

Superfamily Nucleoside diphosphate kinase-like domain
Functional Family Nucleoside diphosphate kinase B

Enzyme Information

2.7.4.6
Nucleoside-diphosphate kinase.
based on mapping to UniProt P22392
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.
-!- Many nucleoside diphosphates can act as acceptors. -!- Many ribo- and deoxyribonucleoside triphosphates can act as donors.
2.7.13.3
Histidine kinase.
based on mapping to UniProt P22392
ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.
-!- This entry has been included to accommodate those protein-histidine kinases for which the phosphorylation site has not been established (i.e. either the pros- or tele-nitrogen of histidine). -!- A number of histones can act as acceptor.

UniProtKB Entries (1)

P22392
NDKB_HUMAN
Homo sapiens
Nucleoside diphosphate kinase B

PDB Structure

PDB 3BBF
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
NM23-H2 may play an indirect role in transcriptional activation of c-myc gene expression but does not cleave the nuclease hypersensitive element III1.
Dexheimer, T.S., Carey, S.S., Zuohe, S., Gokhale, V.M., Hu, X., Murata, L.B., Maes, E.M., Weichsel, A., Sun, D., Meuillet, E.J., Montfort, W.R., Hurley, L.H.
Mol.Cancer Ther.