CATH Domain 3aq0H00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.600	Farnesyl Diphosphate Synthase
	1.10.600.10	Farnesyl Diphosphate Synthase

Domain Context

CATH Clusters

Superfamily	Farnesyl Diphosphate Synthase
Functional Family	Solanesyl diphosphate synthase 3, chloroplastic/mitochondrial

Enzyme Information

2.5.1.85

All-trans-nonaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific).

based on mapping to UniProt Q5HZ00

Geranylgeranyl diphosphate + 5 isopentenyl diphosphate = 5 diphosphate + all-trans-nonaprenyl diphosphate.

-!- Geranylgeranyl diphosphate is preferred over farnesyl diphosphate as allylic substrate. -!- The plant Arabidopsis thaliana has two different enzymes that catalyze this reaction. -!- SPS1 contributes to the biosynthesis of the ubiquinone side-chain while SPS2 supplies the precursor of the plastoquinone side-chains. -!- Formerly EC 2.5.1.11.

UniProtKB Entries (1)

Q5HZ00

SPS3_ARATH

Arabidopsis thaliana

Solanesyl diphosphate synthase 3, chloroplastic/mitochondrial

PDB Structure

PDB	3AQ0
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure and mechanism of an Arabidopsis medium/long-chain-length prenyl pyrophosphate synthase Hsieh, F.-L., Chang, T.-H., Ko, T.-P., Wang, A.H.-J. Plant Physiol.