CATH Classification

Domain Context

CATH Clusters

Superfamily Ricin (A Subunit), domain 2
Functional Family Ricin

Enzyme Information

3.2.2.22
rRNA N-glycosylase.
based on mapping to UniProt Q9M6E9
Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.
-!- Ricin A-chain and related toxins show this activity. -!- Naked rRNA is attacked more slowly than rRNA in intact ribosomes. -!- Naked rRNA from Escherichia coli is cleaved at a corresponding position.

UniProtKB Entries (1)

Q9M6E9
AGGL_ABRPR
Abrus precatorius
Agglutinin-1

PDB Structure

PDB 2ZR1
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A biophysical elucidation for less toxicity of Agglutinin than Abrin-a from the Seeds of Abrus Precatorius in consequence of crystal structure
Cheng, J., Lu, T.H., Liu, C.L., Lin, J.Y.
J.Biomed.Sci.