CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.70.360
Functional Family Cytosolic non-specific dipeptidase

Enzyme Information

3.4.13.18
Cytosol nonspecific dipeptidase.
based on mapping to UniProt Q9D1A2
Hydrolysis of dipeptides, preferentially hydrophobic dipeptides including prolyl amino acids.
-!- Broad specificity, varying somewhat with source species. -!- Activated and stabilized by dithiothreitol and manganese. -!- Inhibited by bestatin and leucine. -!- Belongs to peptidase family M20. -!- Formerly EC 3.4.3.1, EC 3.4.3.2, EC 3.4.3.3, EC 3.4.3.6, EC 3.4.13.1, EC 3.4.13.2, EC 3.4.13.3, EC 3.4.13.8, EC 3.4.13.11, EC 3.4.13.13 and EC 3.4.13.15.

UniProtKB Entries (1)

Q9D1A2
CNDP2_MOUSE
Mus musculus
Cytosolic non-specific dipeptidase

PDB Structure

PDB 2ZOG
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis for substrate recognition and hydrolysis by mouse carnosinase CN2.
Unno, H., Yamashita, T., Ujita, S., Okumura, N., Otani, H., Okumura, A., Nagai, K., Kusunoki, M.
J.Biol.Chem.