CATH Classification

Domain Context

CATH Clusters

Superfamily Glucose-6-phosphate isomerase like protein; domain 1
Functional Family Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Enzyme Information

2.6.1.16
Glutamine--fructose-6-phosphate transaminase (isomerizing).
based on mapping to UniProt Q06210
L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.
-!- Although the overall reaction is that of a transferase, the mechanism involves the formation of ketimine between fructose 6-phosphate and a 6-amino group from a lysine residue at the active site, which is subsequently displaced by ammonia (transamidination). -!- Formerly EC 5.3.1.19.

UniProtKB Entries (1)

Q06210
GFPT1_HUMAN
Homo sapiens
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1

PDB Structure

PDB 2ZJ4
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural analysis of human glutamine:fructose-6-phosphate amidotransferase, a key regulator in type 2 diabetes
Nakaishi, Y., Bando, M., Shimizu, H., Watanabe, K., Goto, F., Tsuge, H., Kondo, K., Komatsu, M.
Febs Lett.