CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Phosphorylase b kinase gamma catalytic chain, liver/testis

Enzyme Information

2.7.11.19
Phosphorylase kinase.
based on mapping to UniProt P15735
2 ATP + phosphorylase b = 2 ADP + phosphorylase a.
-!- Requires calmodulin for activity. -!- The enzyme phosphorylates a specific serine residue in each of the subunits of the dimeric phosphorylase b. -!- For muscle phosphorylase but not liver phosphorylase, this is accompanied by a further dimerization to form a tetrameric phosphorylase. -!- The enzyme couples muscle contraction with energy production via glycogenolysis--glycolysis by catalyzing the Ca(2+)-dependent phosphorylation and activation of glycogen phosphorylase b. -!- The gamma subunit of the tetrameric alpha-beta-gamma-delta enzyme is the catalytic subunit. -!- Formerly EC 2.7.1.38.

UniProtKB Entries (1)

P15735
PHKG2_HUMAN
Homo sapiens
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform

PDB Structure

PDB 2Y7J
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of Human Phosphorylase Kinase, Gamma 2
Muniz, J.R.C., Shrestha, A., Savitsky, P., Wang, J., Rellos, P., Fedorov, O., Burgess-Brown, N., Brenner, B., Berridge, G., Elkins, J.M., Krojer, T., Vollmar, M., Che, K.H., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S.
To be Published