CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Ephrin type-A receptor 5

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt Q03137
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

Q03137
EPHA4_MOUSE
Mus musculus
Ephrin type-A receptor 4

PDB Structure

PDB 2Y6O
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of the Epha4 Protein Tyrosine Kinase Domain in the Apo- and Dasatinib-Bound State.
Farenc, C.J.A., Hameetman, L., Zoutman, W., Tensen, C.P., Siegal, G.
FEBS Lett.