CATH Classification

Domain Context

CATH Clusters

Superfamily Laminin
Functional Family Coagulation factor X

Enzyme Information

3.4.21.6
Coagulation factor Xa.
based on mapping to UniProt P00742
Selective cleavage of Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin.
-!- A blood coagulation factor formed from the proenzyme factor X by limited proteolysis. -!- Factor X is a glycoprotein composed of a heavy chain and a light chain, which are generated from a precursor protein by the excision of the tripeptide RKR and held together by one or more disulfide bonds. -!- The activated factor Xa converts prothrombin to thrombin in the presence of factor Va, Ca(2+) and phospholipids. -!- Scutelarin (EC 3.4.21.60) has similar specificity, but does not require factor Va. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P00742
FA10_HUMAN
Homo sapiens
Coagulation factor X

PDB Structure

PDB 2Y5G
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Molecular Recognition at the Active Site of Factor Xa: Cation-Pi Interactions, Stacking on Planar Peptide Surfaces, and Replacement of Structural Water.
Salonen, L.M., Holland, M.C., Kaib, P.S., Haap, W., Benz, J., Mary, J.L., Kuster, O., Schweizer, W.B., Banner, D.W., Diederich, F.
Chemistry