CATH Classification

Domain Context

CATH Clusters

Superfamily Medium-chain alcohol dehydrogenases, catalytic domain
Functional Family Prostaglandin reductase 2

Enzyme Information

1.3.1.48
15-oxoprostaglandin 13-reductase.
based on mapping to UniProt Q14914
11-alpha-hydroxy-9,15-dioxoprost-5-enoate + NAD(P)(+) = (5Z)-(13E)-11- alpha-hydroxy-9,15-dioxoprosta-5,13-dienoate + NAD(P)H.
-!- Reduces 15-oxoprostaglandins to 13,14-dihydro derivatives. -!- The enzyme from placenta is specific for NAD(+).
1.3.1.74
2-alkenal reductase (NAD(P)(+)).
based on mapping to UniProt Q14914
A n-alkanal + NAD(P)(+) = an alk-2-enal + NAD(P)H.
-!- Highly specific for 4-hydroxynon-2-enal and non-2-enal. -!- Alk-2-enals of shorter chain have lower affinities. -!- Exhibits high activities also for alk-2-enones such as but-3-en-2-one and pent-3-en-2-one. -!- Inactive with cyclohex-2-en-1-one and 12-oxophytodienoic acid. -!- Involved in the detoxification of alpha,beta-unsaturated aldehydes and ketones (cf. EC 1.3.1.102).
1.3.1.-
With NAD(+) or NADP(+) as acceptor.
based on mapping to UniProt Q14914

UniProtKB Entries (1)

Q14914
PTGR1_HUMAN
Homo sapiens
Prostaglandin reductase 1

PDB Structure

PDB 2Y05
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of Human Leukotriene B4 12-Hydroxydehydrogenase in Complex with Nadp and Raloxifene
Yue, W.W., Shafqat, N., Krojer, T., Pike, A.C.W., von Delft, F., Sethi, R., Savitsky, P., Johansson, C., Arrowsmith, C., Weigelt, J., Edwards, A., Bountra, C., Oppermann, U.
To be Published