CATH Classification

Domain Context

CATH Clusters

Superfamily Fumarase/aspartase (N-terminal domain)
Functional Family Adenylosuccinate lyase

Enzyme Information

4.3.2.2
Adenylosuccinate lyase.
based on mapping to UniProt Q7A0G9
(1) N(6)-(1,2-dicarboxyethyl)AMP = fumarate + AMP. (2) (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxamide.
-!- Also acts on 1-(5-phosphoribosyl)-4-(N-succinocarboxamide)-5- aminoimidazole.

UniProtKB Entries (1)

Q7A0G9
PUR8_STAAW
Staphylococcus aureus subsp. aureus MW2
Adenylosuccinate lyase

PDB Structure

PDB 2X75
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of Staphylococcus Aureus Adenylosuccinate Lyase (Purb) and Assessment of its Potential as a Target for Structure-Based Inhibitor Discovery.
Fyfe, P.K., Dawson, A., Hutchison, M.T., Cameron, S., Hunter, W.N.
Acta Crystallogr.,Sect.D