CATH Domain 2wnsB00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.2020

Domain Context

CATH Clusters

Superfamily	3.40.50.2020
Functional Family	Uridine monophosphate synthetase

Enzyme Information

2.4.2.10	Orotate phosphoribosyltransferase. based on mapping to UniProt P11172 Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. -!- The enzyme from higher eukaryotes also catalyzes the reaction listed as EC 4.1.1.23.
4.1.1.23	Orotidine-5'-phosphate decarboxylase. based on mapping to UniProt P11172 Orotidine 5'-phosphate = UMP + CO(2). -!- The enzyme from higher eukaryotes is identical with EC 2.4.2.10.

UniProtKB Entries (1)

UMPS_HUMAN

Homo sapiens

Uridine 5'-monophosphate synthase

PDB Structure

PDB	2WNS
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Human Orotate Phosphoribosyltransferase (Oprtase) Domain of Uridine 5'-Monophosphate Synthase (Umps) in Complex with its Substrate Orotidine 5'-Monophosphate (Omp) Moche, M., Roos, A., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, A., Johansson, I., Karlberg, T., Kotyenova, T., Kotzch, A., Nielsen, T.K., Nyman, T., Persson, C., Sagemark, J., Schueler, H., Schutz, P., Siponen, M.I., Svensson, L., Thorsell, A.G., Tresaugues, L., Vandenberg, S., Weigelt, J., Welin, M., Wisniewska, M., Nordlund, P. To be Published