1 keywords

CATH Domain 2vnaA01

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.90 Alpha-Beta Complex
Topology 3.90.180 Quinone Oxidoreductase; Chain A, domain 1
Homologous Superfamily 3.90.180.10 Medium-chain alcohol dehydrogenases, catalytic domain

Domain Context

CATH Clusters

Superfamily Medium-chain alcohol dehydrogenases, catalytic domain
Functional Family Prostaglandin reductase 2

Enzyme Information

1.3.1.48
15-oxoprostaglandin 13-reductase.
based on mapping to UniProt Q8N8N7
11-alpha-hydroxy-9,15-dioxoprost-5-enoate + NAD(P)(+) = (5Z)-(13E)-11- alpha-hydroxy-9,15-dioxoprosta-5,13-dienoate + NAD(P)H.
-!- Reduces 15-oxoprostaglandins to 13,14-dihydro derivatives. -!- The enzyme from placenta is specific for NAD(+).

UniProtKB Entries (1)

Q8N8N7
PTGR2_HUMAN
Homo sapiens
Prostaglandin reductase 2

PDB Structure

PDB 2VNA
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of Human Zinc-Binding Alcohol Dehydrogenase 1 (Zadh1)
Shafqat, N., Kavanagh, K., Pike, A.C.W., Muniz, J.R.C., Pilka, E., Roos, A.K., Picaud, S., Johansson, C., Smee, C., Fedorov, O., Kochan, G., Edwards, A., Arrowsmith, C.H., Weigelt, J., Bountra, C., von Delft, F., Opperman, U.
To be Published