CATH Classification

Domain Context

CATH Clusters

Superfamily 1.10.8.60
Functional Family DNA polymerase epsilon subunit

Enzyme Information

2.7.7.7
DNA-directed DNA polymerase.
based on mapping to UniProt P56282
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.

UniProtKB Entries (1)

P56282
DPOE2_HUMAN
Homo sapiens
DNA polymerase epsilon subunit 2

PDB Structure

PDB 2V6Z
External Links
Method SOLUTION NMR
Organism
Primary Citation
The Solution Structure of the Amino-Terminal Domain of Human DNA Polymerase Epsilon Subunit B is Homologous to C-Domains of Aaa+ Proteins.
Nuutinen, T., Tossavainen, H., Fredriksson, K., Pirila, P., Permi, P., Pospiech, H., Syvaoja, J.E.
Nucleic Acids Res.