CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.140 | Cytidine Deaminase; domain 2 |
|
3.40.140.10 | Cytidine Deaminase, domain 2 |
Domain Context
CATH Clusters
| Superfamily | Cytidine Deaminase, domain 2 |
| Functional Family | Probable C->U-editing enzyme APOBEC-2 |
Enzyme Information
| 3.5.4.36 |
mRNA(cytosine(6666)) deaminase.
based on mapping to UniProt Q9WV35
Cytosine(6666) in apolipoprotein B mRNA + H(2)O = uracil(6666) in apolipoprotein B mRNA + NH(3).
-!- The apolipoprotein B mRNA editing enzyme complex catalyzes the editing of apolipoprotein B mRNA at cytidine(6666) to uridine, thereby transforming the codon for glutamine-2153 to a termination codon. -!- Editing results in translation of a truncated apolipoprotein B isoform (apoB-48) with distinct functions in lipid transport. -!- The catalytic component (APOBEC-1) contains zinc at the active site.
|
UniProtKB Entries (1)
| Q9WV35 |
ABEC2_MOUSE
Mus musculus
C->U-editing enzyme APOBEC-2
|
PDB Structure
| PDB | 2RPZ |
| External Links | |
| Method | SOLUTION NMR |
| Organism | |
| Primary Citation |
Solution structure of the monomeric form of mouse APOBEC2
To be Published
|