CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.920
Functional Family Transketolase

Enzyme Information

2.2.1.1
Transketolase.
based on mapping to UniProt P27302
Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate.
-!- Wide specificity for both reactants, e.g. converts hydroxypyruvate and R-CHO into CO(2) and R-CHOH-CO-CH(2)OH. -!- The enzyme from the bacterium Alcaligenes faecalis shows high activity with D-erythrose 4-phosphate as acceptor.

UniProtKB Entries (1)

P27302
TKT1_ECOLI
Escherichia coli K-12
Transketolase 1

PDB Structure

PDB 2R5N
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Strain and Near Attack Conformers in Enzymic Thiamin Catalysis: X-ray Crystallographic Snapshots of Bacterial Transketolase in Covalent Complex with Donor Ketoses Xylulose 5-phosphate and Fructose 6-phosphate, and in Noncovalent Complex with Acceptor Aldose Ribose 5-phosphate.
Asztalos, P., Parthier, C., Golbik, R., Kleinschmidt, M., Hubner, G., Weiss, M.S., Friedemann, R., Wille, G., Tittmann, K.
Biochemistry