CATH Classification

Domain Context

CATH Clusters

Superfamily Glutaredoxin
Functional Family Glutathione peroxidase

Enzyme Information

1.11.1.9
Glutathione peroxidase.
based on mapping to UniProt P22352
2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O.
-!- Steroid and lipid hydroperoxides, but not the product of reaction of EC 1.13.11.12 on phospholipids, can act as acceptor, but more slowly than H(2)O(2) (cf. EC 1.11.1.12).

UniProtKB Entries (1)

P22352
GPX3_HUMAN
Homo sapiens
Glutathione peroxidase 3

PDB Structure

PDB 2R37
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of human glutathione peroxidase 3 (selenocysteine to glycine mutant).
Pilka, E.S., Guo, K., Gileadi, O., Rojkowa, A., von Delft, F., Pike, A.C.W., Kavanagh, K.L., Johannson, C., Sundstrom, M., Arrowsmith, C.H., Weigelt, J., Edwards, A.M., Oppermann, U.
TO BE PUBLISHED