CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.920
Functional Family Pyruvate dehydrogenase E1 component

Enzyme Information

1.2.4.1
Pyruvate dehydrogenase (acetyl-transferring).
based on mapping to UniProt P0AFG8
Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO(2).
-!- It is a component (in multiple copies) of the multienzyme pyruvate dehydrogenase complex in which it is bound to a core of molecules of EC 2.3.1.12, which also binds multiple copies of EC 1.8.1.4. -!- It does not act on free lipoamide or lipoyllysine, but only on the lipoyllysine residue in EC 2.3.1.12.

UniProtKB Entries (1)

P0AFG8
ODP1_ECOLI
Escherichia coli K-12
Pyruvate dehydrogenase E1 component

PDB Structure

PDB 2QTC
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
A Dynamic Loop at the Active Center of the Escherichia coli Pyruvate Dehydrogenase Complex E1 Component Modulates Substrate Utilization and Chemical Communication with the E2 Component
Kale, S., Arjunan, P., Furey, W., Jordan, F.
J.Biol.Chem.