CATH Classification
Level | CATH Code | Description |
---|---|---|
4 | Few Secondary Structures | |
4.10 | Irregular | |
4.10.140 | Epsilon-Thrombin; Chain L | |
4.10.140.10 | Thrombin light chain domain |
Domain Context
CATH Clusters
Superfamily | Thrombin light chain domain |
Functional Family |
Enzyme Information
3.4.21.5 |
Thrombin.
based on mapping to UniProt P19221
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
-!- More selective than trypsin and plasmin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.13.
|
UniProtKB Entries (1)
P19221 |
THRB_MOUSE
Mus musculus
Prothrombin
|
PDB Structure
PDB | 2PV9 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Cricetulus |
Primary Citation |
Crystal structures of murine thrombin in complex with the extracellular fragments of murine protease-activated receptors PAR3 and PAR4.
Proc.Natl.Acad.Sci.Usa
|