CATH Classification
Level | CATH Code | Description |
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6 | Special |
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6.20 | Other non-globular |
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6.20.200 | Defensin A-like |
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6.20.200.30 |
Domain Context
CATH Clusters
Superfamily | 6.20.200.30 |
Functional Family | Prostaglandin E synthase 2 |
Enzyme Information
5.3.99.3 |
Prostaglandin-E synthase.
based on mapping to UniProt Q9N0A4
(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate.
-!- Brings about the opening of the epidioxy bridge.
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UniProtKB Entries (1)
Q9N0A4 |
PGES2_MACFA
Macaca fascicularis
Prostaglandin E synthase 2
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PDB Structure
PDB | 2PBJ |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Escherichia |
Primary Citation |
PGH2 degradation pathway catalyzed by GSH-heme complex bound microsomal prostaglandin E2 synthase type 2: the first example of a dual-function enzyme.
Biochemistry
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