CATH Classification

Domain Context

CATH Clusters

Superfamily YjeF N-terminal domain
Functional Family NAD(P)H-hydrate epimerase

Enzyme Information

5.1.99.6
NAD(P)H-hydrate epimerase.
based on mapping to UniProt Q8K4Z3
(1) (6R)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide = (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide. (2) (6R)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate = (6S)-6-beta-hydroxy-1,4,5,6- tetrahydronicotinamide-adenine dinucleotide phosphate.
-!- The enzyme can use either (R)-NADH-hydrate or (R)-NADPH-hydrate as a substrate. -!- Its physiological role is to convert the (R) forms to the (S) forms, which could then be restored to active dinucleotides by EC 4.2.1.93.

UniProtKB Entries (1)

Q8K4Z3
NNRE_MOUSE
Mus musculus
NAD(P)H-hydrate epimerase

PDB Structure

PDB 2O8N
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Biochemical and Structural Characterization of Apolipoprotein A-I Binding Protein, a Novel Phosphoprotein with a Potential Role in Sperm Capacitation.
Jha, K.N., Shumilin, I.A., Digilio, L.C., Chertihin, O., Zheng, H., Schmitz, G., Visconti, P.E., Flickinger, C.J., Minor, W., Herr, J.C.
Endocrinology