CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.880
Functional Family uncharacterized protein LOC100176842 isoform X2

Enzyme Information

3.5.1.2
Glutaminase.
based on mapping to UniProt P37528
L-glutamine + H(2)O = L-glutamate + NH(3).
4.3.3.6
Pyridoxal 5'-phosphate synthase (glutamine hydrolyzing).
based on mapping to UniProt P37528
D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + 3 H(2)O + phosphate.
-!- The ammonia is provided by the glutaminase subunit and channeled to the active site of the lyase subunit by a 100 A tunnel. -!- The enzyme can also use ribulose 5-phosphate and dihydroxyacetone phosphate. -!- The enzyme complex is found in aerobic bacteria, archeae, fungi and plants.

UniProtKB Entries (1)

P37528
PDXT_BACSU
Bacillus subtilis subsp. subtilis str. 168
Pyridoxal 5'-phosphate synthase subunit PdxT

PDB Structure

PDB 2NV2
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure of a bacterial pyridoxal 5'-phosphate synthase complex
Strohmeier, M., Raschle, T., Mazurkiewicz, J., Rippe, K., Sinning, I., Fitzpatrick, T.B., Tews, I.
Proc.Natl.Acad.Sci.Usa