CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
4 | Few Secondary Structures |
|
4.10 | Irregular |
|
4.10.70 | Echistatin |
|
4.10.70.30 |
Domain Context
CATH Clusters
| Superfamily | 4.10.70.30 |
| Functional Family | Disintegrin and metalloproteinase domain-containing protein 17 |
Enzyme Information
| 3.4.24.86 |
ADAM 17 endopeptidase.
based on mapping to UniProt P78536
Narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala-|-Val- Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumor necrosis factor alpha (TNF-alpha). Similarly cleaves other membrane-anchored, cell-surface proteins to 'shed' the extracellular domains.
-!- In vivo, the cleavage of tumor necrosis factor alpha precursor releases the soluble, 17-kDa TNF-alpha, which induces inflammation. -!- Belongs to peptidase family M12.
|
UniProtKB Entries (1)
| P78536 |
ADA17_HUMAN
Homo sapiens
Disintegrin and metalloproteinase domain-containing protein 17
|
PDB Structure
| PDB | 2M2F |
| External Links | |
| Method | SOLUTION NMR |
| Organism | |
| Primary Citation |
Membrane-proximal domain of a disintegrin and metalloprotease-17 represents the putative molecular switch of its shedding activity operated by protein-disulfide isomerase.
J.Am.Chem.Soc.
|