CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.70.370
Functional Family DNA polymerase I

Enzyme Information

2.7.7.7
DNA-directed DNA polymerase.
based on mapping to UniProt P19821
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.

UniProtKB Entries (1)

P19821
DPO1_THEAQ
Thermus aquaticus
DNA polymerase I, thermostable

PDB Structure

PDB 2KTQ
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structures of open and closed forms of binary and ternary complexes of the large fragment of Thermus aquaticus DNA polymerase I: structural basis for nucleotide incorporation.
Li, Y., Korolev, S., Waksman, G.
EMBO J.