CATH Classification

Domain Context

CATH Clusters

Superfamily Cytochrome c1, transmembrane anchor, C-terminal
Functional Family Receptor protein-tyrosine kinase

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt P04626
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P00533
EGFR_HUMAN
Homo sapiens
Epidermal growth factor receptor

PDB Structure

PDB 2KS1
External Links
Method SOLUTION NMR
Organism
Primary Citation
Spatial Structure of the Transmembrane Domain Heterodimer of ErbB1 and ErbB2 Receptor Tyrosine Kinases
Mineev, K.S., Bocharov, E.V., Pustovalova, Y.E., Bocharova, O.V., Chupin, V.V., Arseniev, A.S.
J.Mol.Biol.