CATH Classification

Domain Context

CATH Clusters

Superfamily Cytochrome b5-like heme/steroid binding domain
Functional Family E3 ubiquitin-protein ligase HERC2 isoform X2

Enzyme Information
HECT-type E3 ubiquitin transferase.
based on mapping to UniProt O95714
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)- ubiquitinyl-[acceptor protein]-L-lysine.
-!- In the first step the enzyme transfers ubiquitin from the E2 ubiquitin-conjugating enzyme (EC to a cysteine residue in its HECT domain (which is located in the C-terminal region), forming a thioester bond. -!- In a subsequent step the enzyme transfers the ubiquitin to an acceptor protein, resulting in the formation of an isopeptide bond between the C-terminal glycine residue of ubiquitin and the epsilon- amino group of an L-lysine residue of the acceptor protein. -!- Cf. EC and EC

UniProtKB Entries (1)

Homo sapiens
E3 ubiquitin-protein ligase HERC2

PDB Structure

External Links
Primary Citation
Solution NMR Structure of human protein HS00059
Lemak, A., Gutmanas, A., Fares, C., Quyang, H., Li, Y., Montelione, G., Arrowsmith, C., Dhe-Paganon, S.
To be Published