CATH Classification

Domain Context

CATH Clusters

Superfamily SH2 domain
Functional Family Tyrosine-protein kinase

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt Q03526
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

Q03526
ITK_MOUSE
Mus musculus
Tyrosine-protein kinase ITK/TSK

PDB Structure

PDB 2K7A
External Links
Method SOLUTION NMR
Organism
Primary Citation
Proline isomerization preorganizes the Itk SH2 domain for binding to the Itk SH3 domain.
Severin, A., Joseph, R.E., Boyken, S., Fulton, D.B., Andreotti, A.H.
J.Mol.Biol.