CATH Classification

Domain Context

CATH Clusters

Superfamily S15/NS1, RNA-binding
Functional Family ataxin-3 isoform X1

Enzyme Information

3.4.19.12
Ubiquitinyl hydrolase 1.
based on mapping to UniProt P54252
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
-!- Links to polypeptides smaller than 60 residues are hydrolyzed more readily than those to larger polypeptides. -!- Isoforms exist with quantitatively different specificities among the best known being UCH-L1 and UCH-L3, major proteins of the brain of mammals. -!- Inhibited by ubiquitin aldehyde (in which Gly76 is replaced by aminoacetaldehyde). -!- Belongs to peptidase family C12.

UniProtKB Entries (1)

P0CG48
UBC_HUMAN
Homo sapiens
Polyubiquitin-C

PDB Structure

PDB 2JRI
External Links
Method SOLUTION NMR
Organism
Primary Citation
Understanding the plasticity of the ubiquitin-protein recognition code: the josephin domain of ataxin-3 is a diubiquitin binding motif
Nicastro, G., Menon, R., Masino, L., Pastore, A.
To be Published