CATH Classification

Domain Context

CATH Clusters

Superfamily Dimethylsulfoxide Reductase, domain 2
Functional Family Formate dehydrogenase subunit alpha

Enzyme Information

1.17.1.9
Formate dehydrogenase.
based on mapping to UniProt P07658
Formate + NAD(+) = CO(2) + NADH.
-!- The enzyme from most aerobic organisms is devoid of redox-active centers but that from the proteobacterium Methylosinus trichosporium contains iron-sulfur centers, flavin and a molybdenum center. -!- Together with EC 1.12.1.2, forms a system previously known as formate hydrogenlyase. -!- Formerly EC 1.2.1.2.
1.17.99.7
Formate dehydrogenase (acceptor).
based on mapping to UniProt P07658
Formate + acceptor = CO(2) + reduced acceptor.
-!- Formate dehydrogenase H is a cytoplasmic enzyme that oxidizes formate without oxygen transfer, transferring electrons to a hydrogenase. -!- The two enzymes form the formate-hydrogen lyase complex. -!- The enzyme contains a selenocysteine residue. -!- Formerly EC 1.1.99.33.

UniProtKB Entries (1)

P07658
FDHF_ECOLI
Escherichia coli K-12
Formate dehydrogenase H

PDB Structure

PDB 2IV2
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Formate-Reduced E. Coli Formate Dehydrogenase H: The Reinterpretation of the Crystal Structure Suggests a New Reaction Mechanism.
Raaijmakers, H.C.A., Romao, M.J.
J.Biol.Inorg.Chem.