CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Mitogen-activated protein kinase 6

Enzyme Information

2.7.11.24
Mitogen-activated protein kinase.
based on mapping to UniProt Q16659
ATP + a protein = ADP + a phosphoprotein.
-!- Phosphorylation of specific tyrosine and threonine residues in the activation loop of this enzyme by EC 2.7.12.2 is necessary for enzyme activation. -!- Once activated, the enzyme phosphorylates target substrates on serine or threonine residues followed by a proline. -!- A distinguishing feature of all MAPKs is the conserved sequence Thr- Xaa-Tyr (TXY). -!- Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. -!- Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumor necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischemeic injury. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

Q16659
MK06_HUMAN
Homo sapiens
Mitogen-activated protein kinase 6

PDB Structure

PDB 2I6L
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal Structure of the Human Mitogen Activated Protein Kinase 6
Filippakopoulos, P., Turnbull, A.P., Savitsky, P., Fedorov, O., Berridge, G., Das, S., Elkins, J., Soundararajan, M., Yang, X.W., Doyle, D., Papagrigoriou, E., Pike, A.C.W., Bunkonczi, G., Ugochukwu, E., Debreczeni, J., von Delft, F., Edwards, A., Arrowsmith, C., Sundstrom, M., Knapp, S.
To be Published