CATH Classification

Domain Context

CATH Clusters

Superfamily Glucose-6-phosphate isomerase like protein; domain 1
Functional Family Phosphoheptose isomerase

Enzyme Information

5.3.1.28
D-sedoheptulose 7-phosphate isomerase.
based on mapping to UniProt P63224
D-sedoheptulose 7-phosphate = D-glycero-D-manno-heptose 7-phosphate.
-!- In Gram-negative bacteria the enzyme is involved in biosynthesis of ADP-L-glycero-beta-D-manno-heptose, which is utilized for assembly of the lipopolysaccharide inner core. -!- In Gram-positive bacteria the enzyme is involved in biosynthesis of GDP-D-glycero-alpha-D-manno-heptose, which is required for assembly of S-layer glycoprotein.

UniProtKB Entries (1)

P63224
GMHA_ECOLI
Escherichia coli K-12
Phosphoheptose isomerase

PDB Structure

PDB 2I2W
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure and Function of Sedoheptulose-7-phosphate Isomerase, a Critical Enzyme for Lipopolysaccharide Biosynthesis and a Target for Antibiotic Adjuvants
Taylor, P.L., Blakely, K.M., de Leon, G.P., Walker, J.R., McArthur, F., Evdokimova, E., Zhang, K., Valvano, M.A., Wright, G.D., Junop, M.S.
J.Biol.Chem.