CATH Classification

Domain Context

CATH Clusters

Superfamily Vaccinia Virus protein VP39
Functional Family Thiopurine S-methyltransferase

Enzyme Information

2.1.1.67
Thiopurine S-methyltransferase.
based on mapping to UniProt P51580
S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether.
-!- Also acts, more slowly, on thiopyrimidines and aromatic thiols. -!- Not identical with EC 2.1.1.9.

UniProtKB Entries (1)

P51580
TPMT_HUMAN
Homo sapiens
Thiopurine S-methyltransferase

PDB Structure

PDB 2H11
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural basis of allele variation of human thiopurine-S-methyltransferase.
Wu, H., Horton, J.R., Battaile, K., Allali-Hassani, A., Martin, F., Zeng, H., Loppnau, P., Vedadi, M., Bochkarev, A., Plotnikov, A.N., Cheng, X.
Proteins