CATH Classification

Domain Context

CATH Clusters

Superfamily DNA polymerase family B, C-terminal domain
Functional Family DNA polymerase catalytic subunit

Enzyme Information

2.7.7.7
DNA-directed DNA polymerase.
based on mapping to UniProt P04292
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.
3.1.26.4
Ribonuclease H.
based on mapping to UniProt P04292
Endonucleolytic cleavage to 5'-phosphomonoester.
-!- Acts on RNA-DNA hybrids.

UniProtKB Entries (1)

P04292
DPOL_HHV1K
Human alphaherpesvirus 1 strain KOS
DNA polymerase catalytic subunit

PDB Structure

PDB 2GV9
External Links
Method X-RAY DIFFRACTION
Organism Spodoptera
Primary Citation
Crystal structure of the herpes simplex virus 1 DNA polymerase.
Liu, S., Knafels, J.D., Chang, J.S., Waszak, G.A., Baldwin, E.T., Deibel, M.R., Thomsen, D.R., Homa, F.L., Wells, P.A., Tory, M.C., Poorman, R.A., Gao, H., Qiu, X., Seddon, A.P.
J.Biol.Chem.