CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.10 Roll
Topology 3.10.620 C8orf32 fold
Homologous Superfamily 3.10.620.30  

Domain Context

CATH Clusters

Superfamily 3.10.620.30
Functional Family peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase

Enzyme Information

3.5.1.52
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase.
based on mapping to UniProt Q9JI78
Hydrolysis of an N(4)-(acetyl-beta-D-glucosaminyl)asparagine residue in which the glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and a peptide containing an aspartate residue.
-!- Does not act on (GlcNAc)-Asn, because it requires the presence of more than two amino-acid residues in the substrate (cf. EC 3.5.1.26). -!- Formerly EC 3.2.2.18.

UniProtKB Entries (1)

Q9JI78
NGLY1_MOUSE
Mus musculus
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

PDB Structure

PDB 2F4O
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure of the mouse peptide N-glycanase-HR23 complex suggests co-evolution of the endoplasmic reticulum-associated degradation and DNA repair pathways.
Zhao, G., Zhou, X., Wang, L., Li, G., Kisker, C., Lennarz, W.J., Schindelin, H.
J.Biol.Chem.