CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family focal adhesion kinase 1 isoform X2

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt Q05397
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

Q05397
FAK1_HUMAN
Homo sapiens
Focal adhesion kinase 1

PDB Structure

PDB 2ETM
External Links
Method X-RAY DIFFRACTION
Organism Spodoptera
Primary Citation
Crystal Structure of Focal Adhesion Kinase Domain Complexed with ATP and novel 7H-Pyrrolo [2,3-d] pyrimidine scaffolds
Andersen, C.B., Ng, K., Vu, C., Ficarro, S., Choi, H.-S., Gray, N., He, Y., Lee, C.C.
To be Published