CATH Classification

Domain Context

CATH Clusters

Superfamily Peptidase M1, alanyl aminopeptidase, C-terminal domain
Functional Family Aminopeptidase N

Enzyme Information

3.4.11.2
Membrane alanyl aminopeptidase.
based on mapping to UniProt P04825
Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.
-!- Is not activated by heavy metal ions. -!- Belongs to peptidase family M1. -!- Formerly EC 3.4.1.2, EC 3.4.3.5 and EC 3.4.13.6.

UniProtKB Entries (1)

P04825
AMPN_ECOLI
Escherichia coli K-12
Aminopeptidase N

PDB Structure

PDB 2DQM
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Aminopeptidase N (proteobacteria alanyl aminopeptidase) from Escherichia coli: Crystal structure and conformational change of the methionine 260 residue involved in substrate recognition
Ito, K., Nakajima, Y., Onohara, Y., Takeo, M., Nakashima, K., Matsubara, F., Ito, T., Yoshimoto, T.
J.Biol.Chem.