CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.150 | DNA polymerase; domain 1 |
|
1.10.150.50 | Transcription Factor, Ets-1 |
Domain Context
CATH Clusters
| Superfamily | Transcription Factor, Ets-1 |
| Functional Family | Phosphatidylcholine:ceramide cholinephosphotransferase 1 |
Enzyme Information
| 2.7.8.27 |
Sphingomyelin synthase.
based on mapping to UniProt Q8VCQ6
A ceramide + a phosphatidylcholine = a sphingomyelin + a 1,2-diacyl- sn-glycerol.
-!- The reaction can occur in both directions. -!- Occupies a central position in sphingolipid and glycerophospholipid metabolism. -!- Up- and down-regulation of its activity has been linked to mitogenic and pro-apoptotic signaling in a variety of mammalian cell types. -!- Unlike EC 2.7.8.3 CDP-choline cannot replace phosphatidylcholine as the donor of the phosphocholine moiety of sphingomyelin.
|
UniProtKB Entries (1)
| Q8VCQ6 |
SMS1_MOUSE
Mus musculus
Phosphatidylcholine:ceramide cholinephosphotransferase 1
|
PDB Structure
| PDB | 2D8C |
| External Links | |
| Method | SOLUTION NMR |
| Organism | |
| Primary Citation |
Solution structure of the sam-domain of mouse phosphatidyl ceramidecholinephosphotransferase 1
To be Published
|