CATH Classification

Domain Context

CATH Clusters

Superfamily Alpha-helical ferredoxin
Functional Family Succinate dehydrogenase iron-sulfur subunit

Enzyme Information

1.3.5.1
Succinate dehydrogenase (quinone).
based on mapping to UniProt P0AC47
Succinate + a quinone = fumarate + a quinol.
-!- The enzyme is found in the inner mitochondrial membrane in eukaryotes and the plasma membrane of many aerobic or facultative bacteria. -!- It catalyzes succinate oxidation in the citric acid cycle and transfers the electrons to quinones in the membrane, thus constituting a part of the aerobic respiratory chain (known as complex II). -!- In vivo the enzyme uses the quinone found in the organism - eukaryotic enzymes utilize ubiquinone, bacterial enzymes utilize ubiquinone or menaquinone, and archaebacterial enzymes from the Sulfolobus genus use caldariellaquinone. -!- Cf. EC 1.3.5.4.

UniProtKB Entries (1)

P0A8Q0
FRDC_ECOLI
Escherichia coli K-12
Fumarate reductase subunit C

PDB Structure

PDB 2B76
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Fumarate Reductase and Succinate Oxidase Activity of Escherichia coli Complex II Homologs Are Perturbed Differently by Mutation of the Flavin Binding Domain
Maklashina, E., Iverson, T.M., Sher, Y., Kotlyar, V., Andrell, J., Mirza, O., Hudson, J.M., Armstrong, F.A., Rothery, R.A., Weiner, J.H., Cecchini, G.
J.Biol.Chem.