CATH Domain 2axdS00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.58	Methane Monooxygenase Hydroxylase; Chain G, domain 1
	1.20.58.250	DNA polymerase III-theta

Domain Context

CATH Clusters

Superfamily	DNA polymerase III-theta
Functional Family	DNA polymerase III, theta subunit

Enzyme Information

2.7.7.7

DNA-directed DNA polymerase.

based on mapping to UniProt P0ABS8

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.

UniProtKB Entries (1)

P0ABS8

HOLE_ECOLI

Escherichia coli K-12

DNA polymerase III subunit theta

PDB Structure

PDB	2AXD
External Links	PDBSum Proteopedia
Method	SOLUTION NMR
Organism	Escherichia
Primary Citation	Structure of the theta subunit of Escherichia coli DNA polymerase III in complex with the epsilon subunit Keniry, M.A., Park, A.Y., Owen, E.A., Hamdan, S.M., Pintacuda, G., Otting, G., Dixon, N.E. J.Bacteriol.