CATH Classification

Domain Context

CATH Clusters

Superfamily Ribonuclease H-like superfamily/Ribonuclease H
Functional Family Poly(A)-specific ribonuclease PARN

Enzyme Information

3.1.13.4
Poly(A)-specific ribonuclease.
based on mapping to UniProt O95453
Exonucleolytic cleavage of poly(A) to 5'-AMP.
-!- Cleaves poly(A) in either the single- or double-stranded form.

UniProtKB Entries (1)

O95453
PARN_HUMAN
Homo sapiens
Poly(A)-specific ribonuclease PARN

PDB Structure

PDB 2A1S
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural insight into poly(A) binding and catalytic mechanism of human PARN
Wu, M., Reuter, M., Lilie, H., Liu, Y., Wahle, E., Song, H.
Embo J.