CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.50 | 3-Layer(bba) Sandwich | |
3.50.30 | Glucose Oxidase; domain 1 | |
3.50.30.30 |
Domain Context
CATH Clusters
Superfamily | 3.50.30.30 |
Functional Family |
Enzyme Information
3.4.21.110 |
C5a peptidase.
based on mapping to UniProt P15926
The primary cleavage site is at 67-His-|-Lys-68 in human C5a with a minor secondary cleavage site at 58-Ala-|-Ser-59.
-!- Surface-associated subtilisin-like serine peptidase with very specific substrate specificity. -!- Virulent strains of streptococci, including Streptococcus pyogenes, can evade human detection and phagocytosis by destroying the complement chemotaxin C5a. -!- Cleavage of human C5a by this enzyme reduces the ability of C5a to bind receptors on the surface of polymorphonuclear neutrophil leukocytes (PMNLs) and thereby abolishes its chemotactic properties. -!- Belongs to peptidase family S8A.
|
UniProtKB Entries (1)
P15926 |
C5AP_STRPY
Streptococcus pyogenes
C5a peptidase
|
PDB Structure
PDB | 1XF1 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Escherichia |
Primary Citation |
Structure of the streptococcal cell wall C5a peptidase
Proc.Natl.Acad.Sci.Usa
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