CATH Classification

Domain Context

CATH Clusters

Superfamily Serine-tRNA synthetase, tRNA binding domain
Functional Family Seryl-tRNA synthetase 2, mitochondrial

Enzyme Information

6.1.1.11
Serine--tRNA ligase.
based on mapping to UniProt Q9N0F3
(1) ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser). (2) ATP + L-serine + tRNA(Sec) = AMP + diphosphate + L-seryl-tRNA(Sec).
-!- This enzyme also recognizes tRNA(Sec), the special tRNA for selenocysteine, and catalyzes the formation of L-seryl-tRNA(Sec), the substrate for EC 2.9.1.1.

UniProtKB Entries (1)

Q9N0F3
SYSM_BOVIN
Bos taurus
Serine--tRNA ligase, mitochondrial

PDB Structure

PDB 1WLE
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Dual-mode recognition of noncanonical tRNAs(Ser) by seryl-tRNA synthetase in mammalian mitochondria
Chimnaronk, S., Jeppesen, M.G., Suzuki, T., Nyborg, J., Watanabe, K.
Embo J.