CATH Classification

Domain Context

CATH Clusters

Superfamily 1.50.10.20
Functional Family Terpene cyclase/mutase family member

Enzyme Information

5.4.99.7
Lanosterol synthase.
based on mapping to UniProt P48449
(3S)-2,3-epoxy-2,3-dihydrosqualene = lanosterol.
-!- Formerly EC 1.14.1.3 and EC 1.99.1.13.

UniProtKB Entries (1)

P48449
ERG7_HUMAN
Homo sapiens
Lanosterol synthase

PDB Structure

PDB 1W6K
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Insight Into Steroid Scaffold Formation from the Structure of Human Oxidosqualene Cyclase
Thoma, R., Schulz-Gasch, T., D'Arcy, B., Benz, J., Aebi, J., Dehmlow, H., Hennig, M., Stihle, M., Ruf, A.
Nature