CATH Classification

Domain Context

CATH Clusters

Superfamily Nucleoside Triphosphate Pyrophosphohydrolase
Functional Family Diadenosine hexaphosphate hydrolase

Enzyme Information

3.6.1.61
Diadenosine hexaphosphate hydrolase (ATP-forming).
based on mapping to UniProt Q75UV1
(1) P(1),P(6)-bis(5'-adenosyl)hexaphosphate + H(2)O = 2 ATP. (2) P(1),P(5)-bis(5'-adenosyl)pentaphosphate + H(2)O = ATP + ADP. (3) P(1),P(4)-bis(5'-adenosyl)tetraphosphate + H(2)O = ATP + AMP.
-!- The enzyme hydrolyzes P(1),P(4)-bis(5-guanosyl) tetraphosphate very slowly (cf. EC 3.6.1.17).

UniProtKB Entries (1)

Q75UV1
NDX1_THETH
Thermus thermophilus
Diadenosine hexaphosphate hydrolase

PDB Structure

PDB 1VCD
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal Structure of Nudix Protein Ndx1 from Thermus thermophilus HB8 in binary complex with diadenosine hexaphosphate
Iwai, T., Nakagawa, N., Kuramitsu, S., Masui, R.
To be Published