CATH Classification
Level | CATH Code | Description |
---|---|---|
1 | Mainly Alpha | |
1.20 | Up-down Bundle | |
1.20.142 | Poly(ADP-ribose) Polymerase; domain 1 | |
1.20.142.10 | Poly(ADP-ribose) polymerase, regulatory domain |
Domain Context
CATH Clusters
Superfamily | Poly(ADP-ribose) polymerase, regulatory domain |
Functional Family | Poly [ADP-ribose] polymerase |
Enzyme Information
2.4.2.- |
Pentosyltransferases.
based on mapping to UniProt P09874
|
2.4.2.30 |
NAD(+) ADP-ribosyltransferase.
based on mapping to UniProt P09874
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D- ribosyl)(n+1)-acceptor.
-!- The ADP-D-ribosyl group of NAD(+) is transferred to an acceptor carboxy group on a histone or the enzyme itself, and further ADP- ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units.
|
UniProtKB Entries (1)
P09874 |
PARP1_HUMAN
Homo sapiens
Poly [ADP-ribose] polymerase 1
|
PDB Structure
PDB | 1UK0 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Escherichia |
Primary Citation |
Inhibitor-induced structural change of the active site of human poly(ADP-ribose) polymerase.
Febs Lett.
|