CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.70 | Alpha-Beta Plaits |
|
3.30.70.330 | RRM (RNA recognition motif) domain |
Domain Context
CATH Clusters
| Superfamily | 3.30.70.330 |
| Functional Family | Synaptojanin 2 |
Enzyme Information
| 3.1.3.36 |
Phosphoinositide 5-phosphatase.
based on mapping to UniProt O15056
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl- 1D-myo-inositol 4-phosphate + phosphate.
-!- These enzymes can also remove the 5-phosphate from Ins(1,4,5)P(3) and/or Ins(1,3,4,5)P(4). -!- They are a diverse family of enzymes, with differing abilities to catalyze two or more of the four reactions listed. -!- They are thought to use inositol lipids rather than inositol phosphates as substrates in vivo. -!- All of them can use either or both of PtdIns(4,5)P(2) and PtdIns(3,4,5)P(3) as substrates; this is the main property that distinguishes them from EC 3.1.3.56.
|
UniProtKB Entries (1)
| O15056 |
SYNJ2_HUMAN
Homo sapiens
Synaptojanin-2
|
PDB Structure
| PDB | 1UFW |
| External Links | |
| Method | SOLUTION NMR |
| Organism | |
| Primary Citation |
Solution structure of RNP domain in Synaptojanin 2
To be Published
|