CATH Classification

Domain Context

CATH Clusters

Superfamily Sortase
Functional Family Class A sortase SrtA

Enzyme Information

3.4.22.70
Sortase A.
based on mapping to UniProt Q9S446
The enzyme catalyzes a cell wall sorting reaction in which a surface protein with a sorting signal containing a LPXTG motif is cleaved between the Thr and Gly residue. The resulting threonine carboxyl end of the protein is covalently attached to a pentaglycine cross-bridge of peptidoglycan.
-!- Belongs to peptidase family C60.

UniProtKB Entries (1)

Q9S446
Q9S446_STAAU
Staphylococcus aureus
Class A sortase SrtA

PDB Structure

PDB 1T2P
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
CRYSTAL STRUCTURES OF STAPHYLOCOCCUS AUREUS SORTASE A AND ITS SUBSTRATE COMPLEX
Zong, Y., Bice, T.W., Ton-That, H., Schneewind, O., Narayana, S.V.
J.Biol.Chem.