CATH Classification

Domain Context

CATH Clusters

Superfamily Ribonuclease H-like superfamily/Ribonuclease H
Functional Family DNA polymerase

Enzyme Information

2.7.7.7
DNA-directed DNA polymerase.
based on mapping to UniProt P26811
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.

UniProtKB Entries (1)

P26811
DPOL1_SACS2
Saccharolobus solfataricus P2
DNA polymerase 1

PDB Structure

PDB 1S5J
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Insights into DNA replication: the crystal structure of DNA polymerase B1 from the archaeon Sulfolobus solfataricus
Savino, C., Federici, L., Johnson, K.A., Vallone, B., Nastopoulos, V., Rossi, M., Pisani, F.M., Tsernoglou, D.
Structure