CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.630.30
Functional Family Aminoglycoside N(6')-acetyltransferase type 1

Enzyme Information

2.3.1.82
Aminoglycoside 6'-N-acetyltransferase.
based on mapping to UniProt Q9R381
Acetyl-CoA + kanamycin-B = CoA + N(6')-acetylkanamycin-B.
-!- The antibiotics kanamycin A, kanamycin B, neomycin, gentamicin C(1a), gentamicin C(2), sisomicin and tobramycin are substrates. -!- The antibiotic paromomycin is not a substrate. -!- The 6-amino group of the purpurosamine ring is acetylated. -!- Formerly EC 2.3.1.55.

UniProtKB Entries (1)

Q9R381
AAC6_SALEN
Salmonella enterica subsp. enterica serovar Enteritidis
Aminoglycoside N(6')-acetyltransferase type 1

PDB Structure

PDB 1S3Z
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
A bacterial acetyltransferase capable of regioselective N-acetylation of antibiotics and histones
Vetting, M.W., Magnet, S., Nieves, E., Roderick, S.L., Blachard, J.S.
Chem.Biol.